T Cell Receptor Technology

TCR Therapy Starts from Inside the Cell

Unlike CAR T cells that recognize proteins expressed on the surface, T cell Receptors (TCRs) can recognize tumor-specific proteins on the inside of cells. When tumor-specific proteins are broken into fragments, they show up on the cell surface with another protein called major histocompatibility complex, or MHC. TCRs are engineered to recognize a tumor-specific protein fragment/MHC combination.

Major histocompatibility complex (MHC) class I molecules present peptide antigens for recognition by CD8+ T cell receptors.
The MHC class I molecule presents peptide antigens that are derived from intracellular proteins.
The T cell receptor (TCR) is a heterodimer consisting of two subunits, TCRα and TCRβ. Each subunit contains a constant region that anchors the receptor to the cell membrane and a hypervariable region that functions in antigen recognition.

Moving the Science Forward

TCRs are still in early development but an exciting area of the Juno pipeline. Learn more about the latest advances in the field.