Immunotherapy harnesses the power of the immune system to treat cancer and other serious diseases. Our development of investigational treatments are stepping stones to tomorrow's breakthroughs.
Developing Two Novel Technologies
Juno is developing autologous cellular biologics as an answer to overcoming tumor evasion and potentially eradicating cancer cells. We believe the type of engineered T cell we put in the body matters, and we have developed the capability to manipulate and control the type of cells a patient receives, allowing us to develop potential “best-in-class” products that could deliver optimal therapeutic impact.
Chimeric Antigen Receptor (CAR) T cell Technology
Learn more about how our CAR T cells combine the specificity of an antibody with the cytotoxic properties of killer T cells.
T Cell Receptor (TCR) Technology
Learn more about how our TCR constructs activate and co-stimulate T cells in a coordinated immune response against tumor cells.
OVERCOMING TUMOR EVASION AND RESISTANCE
B cell malignancies—including ALL, CLL, and DLBCL—are some of the most intractable and difficult to treat. It is now widely understood that tumor cells’ ability to develop resistance and/or evade the immune response is likely a key driver of treatment failure.
In healthy individuals, normal T cells are able to identify antigens and effectively kill infected or abnormal cells, including cancer cells.
Tumor cell variants adapt to selective pressure by the immune system and effectively evade the immune system’s surveillance by losing certain antigens, resulting in a lack of T cell recognition and ultimately resistance and/or recurrent disease.
T Cell Inhibition
It has also been shown that tumor cells produce immunosuppressive cytokines, such as IL-10 and TGF-β1, in addition to expressing negative costimulatory molecules like PD-L1 that effectively inhibit T cell activity.
HCPs looking for additional information on CAR T cell science and the latest advancements in cancer immunotherapy, please visit CARTCellScience.com.
ENGINEERED T CELL THERAPIES WILL CONTINUE TO EVOLVE
Juno is currently investigating two technologies – CARs (Chimeric Antigen Receptors) and TCRs (T cell Receptors) – to reprogram T cells from a patient’s own immune system to recognize and attack cancer cells.